Ryan Sessegnon could make his first Spurs appearance in over a year after spending last season on loan in Germany, although fellow youngster Oliver Skipp has been left at home following his impressive performance against Manchester City on Sunday.
Youngsters Alfie Devine, Scarlett, Nile John, Maksim Paskotsi and Cameron Carter-Vickers could all feature, while squad players like Harry Winks, Moussa Sissoko and Jack Clarke will be hoping for minutes, though Joe Rodon misses out with a slight injury sustained during the warm-down after the win over Manchester City.
Heung-min Son, Lucas Moura and Steven Bergwijn were all included on the squad list and could be on the bench, with manager Nuno Espirito Santo confirming at his pre-match press conference that none of the players that started against City would feature from the off in Portugal.
Serge Aurier and Tanguy Ndombele were left off the squad list for the play-off, with the second leg in London next Thursday, raising doubts about their Spurs future.
Tottenham predicted XI (4-3-3): Gollini; Doherty, Romero, Carter-Vickers, Davies; Winks, Sissoko, Lo Celso; Gil, Clarke, Scarlett.
When: Thursday, August 18, 7.30pm BST
Where: Estadio Capital do Movel
Referee: Maurizio Mariani
Tottenham squad from: Lloris, Gollini, Austin, Doherty, Reguilon, Romero, Sanchez, Dier, Sessegnon, Tanganga, Davies, Carter-Vickers, Paskotsi, Hojbjerg, Son, Winks, Gil, Sissoko, Lo Celso, Dele, Bergwijn, Lucas, Clarke, Devine, Scarlett, John
Not involved: Kane, Ndombele, Aurier